Here at Encon Group we deliver hundreds of projects per year for clients locally, nationally and the Caribbean. We welcome the opportunity to partner with you on your next project and we encourage you to learn more about us.
The following section is compiled of just a few projects we have provided Engineering Services for.
Click on the project or Industry and Pleasecontact us today for further information about about these or other projects.
Projects By Industry
At Encon we offer our clients a wide range of engineering and consulting services. We understand that innovative engineering solutions are essential for today's state-of-the-art facilities. Encon's engineering specialists work hand in ...
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Relevant Projects
Qiagen Sciences, Inc. (Germantown, MD)
North American Manufacturing and Research Headquarters
DNA Oligoneucleotide Manufacturing Suites
siRNA Manufacturing Laboratories
4G Manufacturing Expansion
Cangene BioPharma. (Baltimore, MD)
Parenteral Manufacturing and Lyophilizer Expansion
Chiller Plant and Emergency Power Expansion
Vial Filling and Capping Suite Improvements
Warehouse Expansion
Lentigen Corporation (Gaithersburg, MD)
Pilot Scale Cell Culture Production
Lonza (Walkersville, MD)
New Cell Therapy Manufacturing Suites, Base Building and Fit-out
Media Formulation and Sterile Fill Suites
Chiller Plant Expansion
USP Purified Water Generation and Distribution System
WFI Storage and Circualtion Loop
Campus Emergency Power and Distribution
Alexion Pharmaceuticals (Smithfield, RI)
Eculizumab Manufacturing Facility
Human Genome Sciences (Gaithersburg, MD)
Cell Culture Production Train Re-Qualification
Emergency Power Feasibility Studies
MedImmune (Gaithersburg)
Café Renovations
Orchard Ridge Drive Renovations
Frederick Manufacturing Facility BMS Commissioning
George Mason University (Fairfax, VA)
Krasnow Institute Laboratory and Vivarium Facility
Aeras (Rockville, MD)
Building Utility Load Studies
CelSci (Catonsville, MD)
Process Chilled Water System
Labeling Suite HVAC Study
Life Technologies (Frederick, MD)
Executive Way Warehouse and Laboratory Facilities
Huntsville Biotechnology Institute (Huntsville, AL)
Osiris Therapeutics (Baltimore, MD)
Cleanroom Expansion
Client Name and Address :
Alexion Pharmaceuticals, Inc
352 Knotler Dr. Cheshire ,CT
Project Name and Location :
Eculizumab Manufacturing
SmithField, Rhode Island
Project Type :
Life Sciences
Gross Area :
45,000 sf
Approximate Construction Cost :
$49.5M
Completion Date and Status :
August 2009/Complete
Encon’s Role :
Engineering/Construction Management
Encon provided Alexion Pharmaceuticals with a full range of engineering services in their search for and renovation of an appropriate building for their large‐scale biotechnology manufacturing processes. Services provided included site selection, process development, test‐fit, conceptual development, engineering design, procurement, and construction management.
The facility was designed to FDA and EU regulatory requirements. The design included a cGMP mammalian cell culture production train with two 10,000L bioreactors and harvest tank. Support functions included media prep, buffer prep, and buffer hold. Downstream processing functions‐‐pre‐and post‐viral purification suites and bulk filling were also provided. A pilot plant for development of biotechnology products that was integral to the main manufacturing area was also included in the project.
All process and building utilities were upgraded. New water pretreatment, WFI production, and distribution systems were installed, including a 9,000 lph vapor compression still, hot and ambient WFI distributions loops, and a pilot plant WFI system that was isolated from the production WFI system. A new clean steam generation and distribution system was also provided.
Process piping systems, providing the automated operation of five CIP systems and multiple product (media, buffer, and cell culture) transfer systems, were also included in the design. All production area HVAC systems were redesigned to be compliant with current FDA and EU requirements. New air handling units and ductwork systems were installed. The central plant chilled and condenser water systems were redesigned.
Lonza Walkersville
Biggs Ford Road, Walkersville, MD
Lonza 100E Cell Therapy
Walkersville, MD
Life Science
75,000 sf
$15M
November 2010/Active
Design Engineer
Encon provided project management, detailed design and preconstruction services for a 35,000-square-foot Greenfiel building. The design incorporated cGMP manufacturing and support areas for cell culture and downstream manufacturing activities and was designed to meet FDA regulatory requirements.
Process equipment and utility design included water pretreatment and USP purified water generation and distribution, a continuous heat inactivation biowaste kill system, biohazard decontamination steam autoclaves, vaporous hydrogen peroxide decontamination systems, and cell culture media waste removal equipment. Included in the project’s design is a 6 megawatt backup generator facility consisting of four diesel fired generator sets, 10,000 amp paralleling gear, main power distribution gear, and multiple automatic transfer switches located throughout the campus.
Encon provided preconstruction activities consisting of bid package preparation, pre-qualification of contractors, bid document distribution, and bid evaluation and selection, project management and was responsible for the supervision and the coordination of all design disciplines.
Qiagen Sciences, Inc.
Germantown, MD
300,000 sf
Confidential
June 2014/Active
Engineering/Owner’s Representative
Encon is currently providing a full range of engineering services for the design and construction of the 4G Manufacturing Facility expansion project. This is a multi-phase project that will significantly expand QIAGEN’s presence at the location. Services provided include facility programming, process development, engineering design and on-site project management. Encon has also been selected as QIAGEN’s Owners Representative and has a daily on-site presence providing oversight and management of the construction and start-up of the project.
The expansion is being designed as cGMP compliant for the manufacture of a wide variety of diagnostic products for distribution throughout QIAGEN’s worldwide customer base. Manufacturing space, laboratories for product scale up, support offices and meeting rooms, a new office building, a new parking garage, and an expanded utility infrastructure are included in the scope of the project.
The existing utility plant is being upgraded to support the expansion and to provide a more robust and reliable operating facility. New chillers, steam boilers, and high purity systems are being added as well as being integrated into existing systems.
Lentigen Corporation
910 Clopper Road, Gaithersburg, MD
Gaithersburg, MD
30,000 sf
$3.3M
December 2010/ Active
Encon provided project management, conceptual development, detailed design, and construction management services for Lentigen’s new cGMP manufacturing and R&D laboratory facility. The facility is the new location for Lentigen which is moving out of a biotech incubator.
The facility design included class 10,000 clean room suites suitable for concurrent multi-product cell therapy operations in compliance with FDA and EU regulatory requirements. The manufacturing area is designed to meet BSL-2LS regulations.
The cell therapy suites will employ new HVAC systems to meet Lentigen’s stringent contamination control requirements. Design solutions also included a new high purity water system, cGMP compliant autoclave and glassware washer equipment, decontamination autoclave, and process gas and vacuum systems.
Encon also has provided procurement and construction management services for the construction of the facility. Encon has competitively bid all trade contracts, equipment and services and provides daily management and supervision of the jobsite.
Cangene Biopharma
1111 S. Paca St. Baltimore, MD
Cangene BioPharma
Baltimore, MD
Various
Engineering/ Construction Manager
Encon has provided multiple facility and process upgrades for Cangene BioPharma’s Baltimore facility including:
Conceptual planning and design for the retrofit of an existing vaccine facility to accommodate BL-2LS manufacturing of multiple parenteral products. The design was intended for FDA cGMP and EU regulatory compliance. New high purity and plant utilities were provided and included USP water pretreatment, water for injection generation and distribution, bio-kill, and clean steam systems. Upgrade and replacement of autoclaves, depyrogenation ovens, and production lyophilzers were included.
Renovation and expansion of existing aseptic manufacturing for accommodation of increased lyophilization capacity with room pressurization modifications and phased construction requirements.
Quality control and microbiology clean rooms designed to support quality testing and facility monitoring for parenteral drug manufacturing. Design solutions included FDA high purity utility systems, expanded facility chilled water system, compressed gas and vacuum utility systems, bio-safety cabinets, and a high pressure steam system expansion for the existing plant.
Life Science Projects
There are multiple definitions of sustainability. All the definitions marry the following themes:
